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[Researched of PJ34 which is protective effect on the glutamate-induced HT-22 cell damage]
Hong-bin Fan1, Yi-nan Wang, De-qin Geng
1Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
Aim:
To poly ADP ribose polymerase inhibitors PJ34 on glutamate neurotoxicity induced protective effect, as PJ34 in ischemic cerebrovascular disease provide a reference for clinical applications.
Methods:
After the cultured HT-22 cells were treated with 5 mmol/L Glu induction treatment, divided into the PJ34 group subsequently given 50 micromol/L PARP inhibitor PJ34 protection effects processing. Inhibition rate of each group and the PARP activity of changes.
Results:
PJ34 group after 24 h, inhibition rate of HT-22 cells were markedly decreased (P<0.05). PJ34 PARP activity than the control group was significantly lower (P<0.05).
Conclusion:
PJ34 PARP activity by reducing increased glutamate-induced HT-22 cell viability, and thus play a protective effect on cells.
