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Antibodies to various mycoplasmas in patients with coronary heart disease

Leonid Barski1, Roman Nevzorov, Jacob Horowitz

  • 1Department of Medicine F, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. lbarski@bgu.ac.il

The Israel Medical Association Journal : IMAJ
|September 25, 2010
PubMed

Insights

This study found no significant link between mycoplasma infections and coronary heart disease (CHD). Antibody testing in patients with CHD and healthy donors did not reveal a clear association, suggesting mycoplasma may not be a key factor in CHD development.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Epidemiology

Background:

  • Established risk factors do not fully explain coronary heart disease (CHD).
  • The role of infectious agents, like Chlamydia pneumoniae and Mycoplasma pneumoniae, in atherosclerosis is under investigation.
  • Previous studies suggested a potential link between certain mycoplasmal infections and CHD.

Purpose of the Study:

  • To investigate the association between mycoplasmal infections and coronary heart disease (CHD).

Main Methods:

  • A prospective cohort study involved 150 patients with CHD and 98 healthy blood donors.
  • Antibody titers for Mycoplasma pneumoniae, M. fermentans, M. hominis, and Ureaplasma urealyticum were measured.
  • Agglutination tests and enzyme-linked immunosorbent assays were employed to detect antibodies.

Main Results:

  • No significant differences in mycoplasmal antibody titers were observed between patients with acute coronary syndrome (ACS), stable CHD, and healthy controls.
  • The presence of antibodies against various Mycoplasma species did not vary significantly across the study groups.

Conclusions:

  • Measuring specific antibodies did not establish a significant association between mycoplasmal infections and CHD.
  • The findings do not support a direct link between the studied mycoplasmal infections and the development or presence of coronary heart disease.
Abstract

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