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Related Concept Videos

2D NMR: Homonuclear Correlation Spectroscopy (COSY)01:06

2D NMR: Homonuclear Correlation Spectroscopy (COSY)

Homonuclear correlation spectroscopy, or COSY, is a 2-dimensional NMR technique that provides information about coupled protons. Typically, the geminal and vicinal coupling are observed. For example, consider the COSY spectrum of ethyl acetate, where its 1D proton NMR spectrum is plotted along the vertical and horizontal axes with their corresponding chemical shift scale. Three spots on the diagonal corresponding to the three peaks in the 1D proton spectrum are called diagonal peaks. The COSY...
2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)01:19

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

Heteronuclear single-quantum correlation spectroscopy (HSQC) is a 2D NMR technique that reveals one-bond correlations between hydrogen and a heteronucleus. The HSQC experiment is similar to the heteronuclear correlation experiment (HETCOR) but is more sensitive. In the HSQC spectrum, the proton chemical shift is plotted on the horizontal F2 axis, while the 13C chemical shift is plotted on the vertical F1 axis. The corresponding proton and 13C spectra are also shown. The HSQC contour plot does...
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
2D NMR: Overview of Heteronuclear Correlation Techniques01:18

2D NMR: Overview of Heteronuclear Correlation Techniques

Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other axis.
IR Spectroscopy: Molecular Vibration Overview01:24

IR Spectroscopy: Molecular Vibration Overview

When Infrared (IR) radiation passes through a covalently bonded molecule, the bonds transition from lower to higher vibrational levels. The fundamental vibrational motions that result in infrared absorption can be classified as stretching or bending vibrations.
Stretching vibrations are vibrational motions that occur along the bond line, changing the bond length or distance between two bonded atoms. They are further distinguished as symmetric or asymmetric. In symmetric stretching, the...
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

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Related Experiment Video

Updated: Jun 8, 2026

Direct Comparison of Hyperspectral Stimulated Raman Scattering and Coherent Anti-Stokes Raman Scattering Microscopy for Chemical Imaging
09:46

Direct Comparison of Hyperspectral Stimulated Raman Scattering and Coherent Anti-Stokes Raman Scattering Microscopy for Chemical Imaging

Published on: April 28, 2022

High resolution coherent 2D spectroscopy.

Peter C Chen1

  • 1Chemistry Department, Spelman College, 350 Spelman Lane, Atlanta, Georgia 30314, USA.

The Journal of Physical Chemistry. A
|September 25, 2010
PubMed
Summary
This summary is machine-generated.

Coherent two-dimensional spectroscopy offers a powerful new method for analyzing complex gas-phase molecular electronic spectra. This technique reveals informative patterns, overcoming limitations of traditional methods for congested or perturbed spectra.

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High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy
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High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy

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Last Updated: Jun 8, 2026

Direct Comparison of Hyperspectral Stimulated Raman Scattering and Coherent Anti-Stokes Raman Scattering Microscopy for Chemical Imaging
09:46

Direct Comparison of Hyperspectral Stimulated Raman Scattering and Coherent Anti-Stokes Raman Scattering Microscopy for Chemical Imaging

Published on: April 28, 2022

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy
10:40

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy

Published on: June 28, 2016

Area of Science:

  • Physical Chemistry
  • Molecular Spectroscopy
  • Quantum Dynamics

Background:

  • Conventional high-resolution spectra can be congested and difficult to interpret.
  • Perturbing effects like conical intersections often complicate spectral analysis.
  • One-dimensional spectra may appear patternless in complex molecular systems.

Purpose of the Study:

  • To describe recent advancements in coherent two-dimensional spectroscopy (2DCoherent).
  • To highlight the application of 2DCoherent for gas-phase molecular electronic spectroscopy.
  • To demonstrate the technique's ability to resolve complex spectral features.

Main Methods:

  • Utilizing coherent two-dimensional spectroscopy (2DCoherent).
  • Analyzing spectral patterns in two orthogonal frequency domains.
  • Employing peak clustering to separate rotational and vibrational information.
  • Applying multiple clusters to manage spectral congestion.

Main Results:

  • 2DCoherent spectra reveal informative patterns where 1D spectra are patternless.
  • The technique successfully resolves complex and congested molecular spectra.
  • It enables the study of spectra previously resistant to analysis due to perturbations.
  • Graphical separation of rotational and vibrational information is achieved.

Conclusions:

  • Coherent two-dimensional spectroscopy is a powerful tool for high-resolution electronic spectroscopy of gas-phase molecules.
  • This technique overcomes limitations of conventional methods for complex and perturbed spectra.
  • Innovations in peak clustering enhance spectral analysis and information extraction.