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[Interrelationship between the Bcg and Tbc-1 genes].

B V Nikonenko, A S Apt, M B Mezhlumova

    Genetika
    |December 1, 1990
    PubMed
    Summary

    Genetic analysis revealed that mouse genes Bcg and Tbc-1 complement each other, enhancing resistance to tuberculosis. Further studies confirmed mouse chromosome 1 does not regulate this resistance.

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    Area of Science:

    • Genetics
    • Immunology
    • Microbiology

    Context:

    • Investigating genetic factors influencing tuberculosis (TB) susceptibility in mice.
    • Understanding the interaction between the Bcg gene and Tbc-1 gene in host defense against Mycobacterium tuberculosis.

    Purpose:

    • To elucidate the genetic basis of resistance to Mycobacterium tuberculosis H37Rv infection.
    • To determine the role of the Tbc-1 gene and its relationship with the Bcg gene in conferring TB resistance.
    • To map the Tbc-1 gene's location relative to mouse chromosome 1.

    Summary:

    • F1 hybrids between tuberculosis-susceptible I/St (Tbc-1s) mice and Bcgs-carrying strains exhibited high resistance to M. tuberculosis H37Rv.
    • This resistance suggests a complementary interaction between the Bcg and Tbc-1s genes.
    • Analysis of backcrossed offspring indicated that mouse chromosome 1 does not regulate resistance to M. tuberculosis H37Rv infection.
    • The Tbc-1s gene was found not to be linked to mouse chromosome 1, using the fzy gene as a marker.

    Impact:

    • Provides insights into the genetic architecture of tuberculosis resistance in mammals.
    • Identifies potential gene targets for developing novel strategies against tuberculosis.
    • Contributes to the understanding of host-pathogen interactions in infectious diseases.

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