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Nerve growth factor, birth outcome and pre-eclampsia

Anitha Kilari1, Savita Mehendale, Hemlata Pisal

  • 1Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India.

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|September 25, 2010
PubMed

The present study compares nerve growth factor (NGF) levels between preeclamptic (PE) (n=86) and normotensive (NT) women (n=105) and their associations with blood pressure and infant size. Maternal plasma NGF levels were reduced (p<0.05) in the PE group as compared to the NT group. Furthermore, NGF levels were reduced in PE mothers delivering low birth weight babies (LBW) as compared to NT mothers delivering LBW babies. Maternal NGF levels were negatively (p=0.029) associated with blood pressure in preeclamptic mothers. Cord NGF levels were negatively associated (p=0.026) with birth weight in the normotensive group. NGF levels are differently regulated in preeclamptic and normotensive mothers delivering LBW babies. Future studies need to investigate mechanisms underlying this pathophysiology and follow-up of these babies to better understand the role of NGF in brain development in later life.

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