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Related Experiment Videos

[Non-Hodgkin's lymphoma simulating chorioretinitis].

H Reim1, R Dieler, A Wessing

  • 1Augenklinik, Medizinischen Fakultät der RWTH, Aachen, Bundesrepublik Deutschland.

Fortschritte Der Ophthalmologie : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|January 1, 1990
PubMed
Summary

Ocular lymphoma, a rare Non-Hodgkin's lymphoma, can present as chorioretinitis. This study highlights two cases of malignant T-cell lymphoma affecting the eyes, with one progressing to fatal neurological involvement.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Neurology

Background:

  • Ocular lymphoma, a subtype of Non-Hodgkin's lymphoma, was previously known as reticulum cell sarcoma.
  • It is characterized by high malignancy and can manifest as posterior uveitis with vitreous opacities.

Observation:

  • Two female patients presented with atypical ocular lymphoma, showing minor vitreous opacities allowing for funduscopic examination.
  • The first patient exhibited confluent chorioretinal infiltrates, progressing to neurological symptoms and death due to multifocal lymphoma infiltration.
  • The second patient displayed subretinal infiltrates near the optic nerve, which resolved spontaneously, leaving pigment epithelial atrophy.

Findings:

  • Malignant T-cell lymphoma was confirmed as the cause of ocular and systemic involvement in the first patient.

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  • The second patient's case demonstrated a rare, self-resolving course of ocular lymphoma.
  • The study underscores the varied clinical presentations and potential systemic impact of ocular lymphoma.

    • Implications:

    • Early diagnosis of ocular lymphoma is crucial, even with subtle findings.
    • Ocular lymphoma can have diverse clinical trajectories, ranging from rapidly fatal to spontaneously resolving.
    • This condition necessitates a multidisciplinary approach involving ophthalmology, oncology, and neurology for comprehensive patient management.