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Updated: Jun 8, 2026

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
Characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnostics
Andreas N Schüring1, Nicole Schulte, Reinhard Kelsch
1Department of Gynecology and Obstetrics, University Clinic of Münster, Münster, Germany. Andreas.Schuering@ukmuenster.de
Abstract:
Endometrial cell clones derived from in vitro cultured purified stromal cells obtained by endometrial biopsy display characteristic stem cell features, including clonality; long-term culturing properties; multilineage differentiation potential; expression of CD146, CD105, CD90, CD73, MSI1, NOTCH1, and SOX2; and absence of CD34 and CD14 expression. We conclude that adult stem cells are present in endometrial biopsies performed in a routine clinical setting, offering new large-scale approaches for future research, diagnostics, and therapies involving adult stem cells.

