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Updated: Jun 8, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating
Patrick Bippus1, Matthias Skocic, Michael A Jakupec
1Fachbereich C-Anorganische Chemie, Bergische Universität Wuppertal, Wuppertal, Germany.
Abstract:
The thiocarbamates 4-RC(6)H(4)NHC(S)NR(2)' (R=H, Cl; R'=Me, Et), 4-ClC(6)H(4)NHC(S)NR (NR=2-pyridylpiperazine) react with cis-[PtCl(2)(PTA)(2)] (PTA=1,3,5-triaza-7-phosphaadamantane) in the presence of base to afford the monocationic platinum(II) complexes cis-[Pt{SC(NR(2)')=NC(6)H(4)R}(PTA)(2)](+) (R=H, Cl; R'=Me, Et), cis-[Pt{SC(NR)=NC(6)H(4)Cl}(PTA)(2)](+) (NR=2-pyridylpiperazine), which were isolated as their PF(6) salts in high yields. The complexes were fully characterised spectroscopically and also by X-ray crystallography. Cytotoxicity of these complexes was studied in vitro in three human cancer cell lines (CH1, A549 and SW480) using the MTT assay.
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