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Related Experiment Video

Updated: Jun 8, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
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Published on: July 1, 2021

Heat acclimation improves cutaneous vascular function and sweating in trained cyclists.

Santiago Lorenzo1, Christopher T Minson

  • 1Department of Human Physiology, University of Oregon, Eugene, OR 97403-1240, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 25, 2010
PubMed
Summary
This summary is machine-generated.

Heat acclimation enhances skin blood flow and sweating responses in trained cyclists by improving local microcirculation, without altering maximal blood flow capacity. This indicates adaptations in cutaneous vascular function, not structural changes.

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Area of Science:

  • Exercise Physiology
  • Thermoregulation
  • Human Physiology

Background:

  • Heat acclimation improves the body's ability to cope with heat stress.
  • Understanding adaptations in cutaneous vascular responses and sweating is crucial for optimizing athletic performance in hot environments.
  • Previous research has not fully elucidated the specific microcirculatory adaptations following heat acclimation in highly trained individuals.

Purpose of the Study:

  • To investigate the effects of heat acclimation on cutaneous vascular conductance (CVC) and sweat rate in response to local acetylcholine (ACh) infusions.
  • To determine if heat acclimation alters maximal skin blood flow.
  • To examine local adaptations within the skin microcirculation and sweat gland apparatus after heat acclimation.

Main Methods:

  • Twenty highly trained cyclists underwent a 10-day heat acclimation program or control conditions.
  • Local skin blood flow was measured using laser-Doppler flowmetry (LDF) during microdialysis with varying concentrations of ACh.
  • Cutaneous vascular conductance (CVC) was calculated, and sweat rate was measured by resistance hygrometry. Maximal forearm blood flow was assessed via Doppler ultrasound.

Main Results:

  • Heat acclimation significantly increased CVC responses to ACh infusions (1, 10, and 100 mM).
  • Sweating responses to 10 and 100 mM ACh infusions were significantly elevated post-heat acclimation.
  • Maximal forearm blood flow remained unchanged, indicating no alteration in maximal vasodilator capacity.

Conclusions:

  • Heat acclimation induces local adaptations in the skin's microcirculation and sweat gland function in highly trained individuals.
  • The observed improvements in cutaneous vascular responses are due to enhanced vasodilator function, not structural changes limiting maximal blood flow.
  • These findings highlight the specific physiological adaptations contributing to improved thermoregulation after heat acclimation.