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Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

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Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment
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Cardiac transplantation: five years' activity.

Manuel J Antunes1, David Prieto, Emília Sola

  • 1Programa de Transplantação Cardíaca, Centro de Cirurgia Cardiotorácica, Hospitais da Universidade Coimbra, Coimbra, Portugal. antunes.cct.huc@sapo.pt

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|September 28, 2010
PubMed
Summary

The Coimbra University Hospitals heart transplant program achieved 90% one-year and 82% five-year survival rates in its initial five years. These results demonstrate the program

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Area of Science:

  • Cardiology
  • Transplant Surgery
  • Immunology

Background:

  • The establishment of new heart transplant programs is crucial for expanding access to life-saving treatments.
  • Analyzing early outcomes is essential for program refinement and demonstrating efficacy.

Purpose of the Study:

  • To evaluate the initial five-year experience of the heart transplant program at Coimbra University Hospitals.
  • To assess patient and graft survival rates, complications, and overall program performance.

Main Methods:

  • A retrospective analysis of 132 heart transplant recipients between November 2003 and December 2008.
  • Data collection included patient demographics, donor characteristics, surgical techniques, immunosuppression protocols, and clinical outcomes.
  • Kaplan-Meier survival analysis was used to determine actuarial survival rates.

Main Results:

  • Actuarial survival rates at one and five years were 90% and 82%, respectively.
  • Early mortality (within 30 days) was 4.5%, primarily due to graft failure and hyperacute rejection.
  • Late mortality (after 30 days) was 10%, with cancer and infection being the leading causes. Rejection episodes were managed effectively with immunosuppression adjustments.

Conclusions:

  • The Coimbra University Hospitals heart transplant program achieved outcomes comparable to or better than established centers.
  • The program has successfully increased the rate of cardiac transplantation in Portugal, exceeding the European average.
  • Continuous self-correction based on program experience has been key to its success.