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Wells' syndrome (eosinophilic cellulitis)--case report and electron microscopic studies
K C Wong1, J K Hwang, C K Wong
1Department of Dermatology, National Yang-Ming Medical College, Taiwan, Republic of China.
The Journal of Dermatology
|December 1, 1990
Summary
Wells' syndrome, a form of eosinophilic cellulitis, presents with skin swelling and infiltration. This case study highlights its unique histopathology and successful treatment with oral antihistamines.
Area of Science:
- Dermatology
- Pathology
Background:
- Wells' syndrome, also known as eosinophilic cellulitis, is a rare inflammatory skin condition.
- It is characterized by recurrent episodes of acute cutaneous swelling and infiltration.
Observation:
- This report details a specific case of Wells' syndrome exhibiting acute swelling followed by indolent dermal infiltration.
- Histopathology revealed a dense infiltrate of eosinophils and characteristic 'flame figures' within the dermis.
- Peculiar electron microscopic findings were also noted.
Findings:
- The patient's condition responded favorably to treatment with oral antihistamines.
- Complete resolution of skin signs and symptoms was observed within two weeks of treatment initiation.
Implications:
- This case underscores the efficacy of oral antihistamines in managing Wells' syndrome.
- Further research into the unique histopathological and electron microscopic features may enhance diagnostic and therapeutic strategies for eosinophilic dermatoses.