Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adenosine deaminase activity in leprosy.

S S Suri Babu1, K B Kannan, V M Katoch

  • 1Dept. of Biochemistry, Central JALMA Institute for Leprosy, Taj Ganj, Agra.

Indian Journal of Leprosy
|October 1, 1990
PubMed
Summary

Leprosy patients show elevated adenosine deaminase (ADA) activity in serum and lymphocytes. Tuberculoid leprosy cases exhibit higher ADA levels than lepromatous cases, suggesting immune cell proliferation rather than enzyme deficiency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome to Om: Evolving journey of modern science to meta-science.

The Indian journal of medical research·2025
Same author

Diagnosis & management of infections due to non-tuberculous mycobacteria in developing countries: Looking ahead.

The Indian journal of medical research·2020
Same author

Planning action for strengthening the ecosystem for Ayurvedic research.

Journal of Ayurveda and integrative medicine·2018
Same author

Rapid detection of ethambutol-resistant <i>Mycobacterium tuberculosis</i> in clinical specimens by real-time polymerase chain reaction hybridisation probe method.

Indian journal of medical microbiology·2018
Same author

Expression profile of CXCL12 chemokine during M. tuberculosis infection with different therapeutic interventions in guinea pig.

The Indian journal of tuberculosis·2018
Same author

Predominance of Central Asian and European families among Mycobacterium tuberculosis isolates in Kashmir Valley, India.

The Indian journal of tuberculosis·2017

Area of Science:

  • Immunology
  • Biochemistry
  • Infectious Diseases

Background:

  • Leprosy, caused by Mycobacterium leprae, presents diverse clinical forms.
  • Cellular immune responses are crucial in determining leprosy type.
  • Adenosine deaminase (ADA) is an enzyme involved in lymphocyte differentiation and function.

Purpose of the Study:

  • To investigate adenosine deaminase (ADA) activity in serum and lymphocytes of leprosy patients.
  • To compare ADA levels between different leprosy types (tuberculoid and lepromatous) and healthy controls.

Main Methods:

  • Measurement of serum and peripheral blood lymphocyte adenosine deaminase (ADA) activity.
  • Comparison of ADA levels across patient groups and controls.

Main Results:

  • Serum ADA levels were elevated in both tuberculoid and lepromatous leprosy compared to controls.
  • Serum ADA activity was significantly higher in tuberculoid leprosy than in lepromatous leprosy.
  • Lymphocyte ADA activity followed a similar trend, higher in tuberculoid than lepromatous leprosy.

Conclusions:

  • Overall ADA activity is not deficient in leprosy.
  • Elevated ADA suggests abnormal lymphocyte proliferation in response to M. leprae.
  • Immune aberrations in leprosy may stem from differential lymphocyte subset proliferation.

Related Experiment Videos