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Updated: Jun 8, 2026

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
Published on: March 5, 2017
Long-range protein coupling mediated by critical low-energy modes of tubular lipid membranes
Sylvain Monnier1, Sergei B Rochal, Andrea Parmeggiani
1Laboratoire de Physique Théorique et Astroparticules, CNRS, Université Montpellier II, Pl. E. Bataillon, 34095 Montpellier Cedex 5, France.
Abstract:
We develop a theory of a resonant effect in protein-membrane coupling taking place in the vicinity of instabilities in tubular lipid membranes (TLMs) under longitudinal force and pressure difference constraints. Two critical low-energy modes defining the stability domain boundaries are found. We show that these modes mediate long-range TLM-protein coupling and interactions between absorbed proteins. Besides, TLM mechanical instabilities strongly influence protein desorption and protein cluster nucleation on TLMs. Model predictions can be tested over a large spectrum of mechanochemical conditions.
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