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Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ
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Physical limits on cellular sensing of spatial gradients

Bo Hu1, Wen Chen, Wouter-Jan Rappel

  • 1Department of Physics and Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, California 92093-0374, USA.

Physical Review Letters
|September 28, 2010
PubMed
Summary

Cell size and receptor cooperativity enhance gradient sensing accuracy. Receptor coupling may enable small bacteria to measure chemical gradients, overcoming limitations from particle binding fluctuations.

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