Related Experiment Video
Updated: Jun 8, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
A Th1 but not a Th17 response is present in the gastrointestinal involvement of Behçet's disease
Angelo Ferrante1, Francesco Ciccia, Alfonso Principato
1Dipartimento Biomedico di Medicina Interna e Specialistica, Palermo University School of Medicine, Palermo, Italy. angelo_ferrante@msn.com
Objectives:
Behçet's disease has been historically classified as a Th1 disease. The recently described IL-17/IL-23 pathway seems to play an important role in many inflammatory diseases and in the intestinal abnormalities of AS and CD. The aim of the present study was to evaluate the IL-17/IL-23 axis in parallel with Th1 and IL-27 response in the intestine of patients with BD and gastrointestinal abnormalities.
Methods:
Quantitative TaqMan reverse transcriptase-polymerase chain reaction (RT-PCR) was utilised for all determinations on ileal biopsy specimens obtained from BD, AS and CD patients. The serum levels of Th1 and Th17 cytokines were evaluated by enzyme-linked immunosorbent assay.
Results:
A Th1 but not a Th17 response is present in the gastrointestinal involvement of Behçet's disease.
Conclusions:
Although BD shares clinical manifestations with both CD and AS, the immunologic abnormalities seen in the intestine are quite different, indicating that other immune mechanisms should be taken into account.
Related Concept Videos
Inflammatory Bowel Disease III: Crohn's Disease
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Inflammatory Bowel Disease II: Ulcerative Colitis
Gastritis II: Pathophysiology
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction

