Related Experiment Video
Updated: Jun 8, 2026

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position
Published on: April 1, 2022
Neoaortic valve and root complex evolution after Ross operation in infants, children, and adolescents
Alessandro Frigiola1, Alessandro Varrica, Angela Satriano
1Department of Cardiac Surgery, IRCCS Policlinico S. Donato, Milan, Italy.
Insights
The Ross operation is a viable option for pediatric aortic valve disease. While neoaortic dilation occurs, it doesn't cause valve insufficiency, the primary reason for reoperation.
Area of Science:
- Cardiovascular Surgery
- Pediatric Cardiology
- Aortic Valve Disease
Background:
- The Ross operation offers advantages for children and adolescents with aortic valve disease.
- Concerns exist regarding long-term neoaortic complex development and dilation risk.
Purpose of the Study:
- To evaluate the long-term outcomes of the Ross operation in pediatric patients.
- To assess neoaortic complex development, valve function, and reoperation rates.
Main Methods:
- Retrospective analysis of prospectively collected data from 95 patients under 18 years old who underwent the Ross operation.
- Median follow-up of 84 months, analyzing echocardiographic and clinical data.
Main Results:
- Neoaortic root and sinotubular junction dilation exceeded somatic growth; neoaortic valve growth mirrored somatic proportions.
- Freedom from moderate neoaortic root dilation was 100% at 5 years and 77% at 10 years.
- Freedom from moderate neoaortic valve insufficiency was 86% at 5 years and 63% at 10 years; freedom from reintervention was 96% at 5 years and 80% at 10 years.
Conclusions:
- The Ross operation is a viable option for severe aortic valve disease in children and adolescents.
- Neoaortic complex dilation occurs but is not the primary driver of neoaortic valve insufficiency.
- Neoaortic valve insufficiency is the main indication for reoperation after the Ross procedure.
Background:
The Ross operation in children and adolescents offers many potential advantages. Concerns have been raised about the long-term development of the neoaortic complex and the risk of dilation.
Methods:
Retrospective analysis of prospectively collected follow-up data in a population of patients who underwent Ross operations when they were younger than 18 years old was conducted. Echocardiographic and clinical data, including survival, need for reoperations, and quality of life, were analyzed in 95 patients for a median follow-up of 84 months.
Results:
The neoaortic root and sinotubular junction demonstrated dilation that exceeded somatic growth. The neoaortic valve grew in a manner that reflected somatic proportions. Freedom from moderate neoaortic root dilation was 100% at 5 years and 77% after 10 years. Freedom from moderate neoaortic valve insufficiency was 86% at 5 years after the Ross procedure and 63% after 10 years. The use of a proximal anastomosis running suture (p = 0.005) and the degree of neoaortic valve insufficiency (p = 0.032) at discharge were independently associated with the degree of neoaortic valve insufficiency at follow-up. Freedom from neoaortic reintervention was 96% at the 5-year follow-up and 80% at the 10-year follow-up. Predictors of neoaortic reintervention were the use of an operative technique other than aortic root replacement (p = 0.002) and the degree of neoaortic valve insufficiency at discharge (p = 0.005).
Conclusions:
The Ross operation remains a viable option for children and adolescents with severe aortic valve disease; neoaortic complex dilation occurs but is not directly responsible for neoaortic valve insufficiency, which is the main cause for reoperation.
Related Concept Videos
Aortic Regurgitation I: Introduction
Mitral Stenosis I: Introduction
Mitral Regurgitation I: Introduction
Aortic Regurgitation III: Medical Management
Heart Valves
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests

