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Related Experiment Video

Updated: Jun 8, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Bridging the gap between MRI and postmortem research in autism.

Cynthia Mills Schumann1, Christine Wu Nordahl

  • 1University of California, Davis School of Medicine, Department of Psychiatry and Behavioral Sciences, The MIND Institute, Sacramento, CA 95817, USA. cschumann@ucdavis.edu

Brain Research
|September 28, 2010
PubMed
Summary

Autism is a neurodevelopmental disorder. Integrating magnetic resonance imaging (MRI) and postmortem brain studies is crucial for understanding autism

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Autism Spectrum Disorder Research

Background:

  • Autism is a neurodevelopmental disorder with unclear pathology.
  • Typical brain development involves neuron proliferation, migration, synaptogenesis, and pruning.

Purpose of the Study:

  • To review the strengths and limitations of MRI and postmortem studies in autism research.
  • To explore how these methods can complement each other to elucidate autism neuropathology.

Main Methods:

  • Review of existing magnetic resonance imaging (MRI) studies in autism.
  • Analysis of postmortem human brain research findings in autism.
  • Discussion of the integration of imaging and tissue-based research.

Main Results:

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Last Updated: Jun 8, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
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  • MRI studies reveal aberrant brain growth trajectories in early childhood, particularly in the amygdala.
  • Postmortem studies offer high-resolution insights into neurobiological underpinnings.
  • Each method has unique strengths and limitations.

Conclusions:

  • Integrating MRI and postmortem brain research is essential for a comprehensive understanding of autism neuropathology.
  • Synergistic use of these approaches can refine hypotheses and target research efforts.
  • Further integration is key to fully explaining the brain pathology in autism.