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Updated: Jun 8, 2026
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
[Genetic diseases and glioblastomas].
F Almairac1, M Frenay, P Paquis
1Service de neurochirurgie, hôpital Pasteur, CHU de Nice, 30, avenue de la voie Romaine, 06000 Nice, France. fabien.almairac@gmail.com
Inherited genetic syndromes are linked to about 1% of gliomas, particularly glioblastomas. Understanding these familial cancer predispositions is crucial for diagnosis and genetic counseling.
Area of Science:
- Oncology
- Genetics
- Neuro-oncology
Context:
- Approximately 1% of gliomas are associated with inherited genetic syndromes.
- Limited data exist on glioblastoma characteristics within these syndromes.
- Familial glioma cases highlight the need to explore genetic underpinnings.
Purpose:
- To review glioblastomas associated with known familial cancer predisposition syndromes.
- To discuss statistical, clinical, and molecular data for these glioblastomas.
- To explore gliomagenesis mechanisms in non-syndromic glioma families.
Summary:
- This review examines glioblastomas in the context of inherited syndromes like neurofibromatosis type 1, Li-Fraumeni's syndrome, tuberous sclerosis, and Turcot's syndrome.
- It consolidates current knowledge on the statistical, clinical, and molecular aspects of these related glioblastomas.
- The review also addresses non-syndromic glioma families, emphasizing the importance of understanding molecular abnormalities for gliomagenesis insights.
Impact:
- Highlights the importance of identifying inherited factors in malignant glioma cases.
- Underscores the need for physicians to consider genetic counseling for patients with suspected inherited predispositions.
- Aims to improve understanding of glioblastoma development and familial cancer risks.
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