[Local antitumor treatments]
1Département de neurochirurgie, CHU d'Angers, 4, rue Larrey, 49940 Angers cedex 9, France. phmenei@chu-angers.fr
Neuro-Chirurgie
|September 28, 2010
Abstract:
The idea of intraoperative adjuvant treatment is not new. This review describes only the strategies studied in phase III clinical trials. Among these strategies, only Gliadel® obtained marketing authorization. Some immunotoxins, administered by convection-enhanced delivery, and a gene therapy approach using an adenovirus went through a phase II trial and are currently being studied in a phase III trial. Brachytherapy has never been validated by a clinical trial.
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