Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of supramaximal resection in glioblastoma: A review.

Neuro-Chirurgie·2026
Same author

Expertise in surgical neuro-oncology. Results of a survey by the EANS neuro-oncology section.

Brain & spine·2024
Same author

Patch-based 3D U-Net and transfer learning for longitudinal piglet brain segmentation on MRI.

Computer methods and programs in biomedicine·2021
Same author

EANO-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Security and reliability of CUSTOMBONE cranioplasties: A prospective multicentric study.

Neuro-Chirurgie·2021
Same author

Acute intracranial hypertension management in metastatic brain tumor: A French national survey.

Neuro-Chirurgie·2019
Same journal

Full-endoscopic monoportal wiltse paraspinal approach with inferior foraminal docking for extraforaminal lumbar disc herniation and foraminal stenosis: technical note and preliminary clinical outcomes.

Neuro-Chirurgie·2026
Same journal

Beyond "Time to Surgery": a structured evidence review and multi-clock framework for emergency cranial neurosurgery.

Neuro-Chirurgie·2026
Same journal

Clinical predictors of overall survival in very elderly patients with spinal osteosarcoma: an analysis of the surveillance, epidemiology, and end results database.

Neuro-Chirurgie·2026
Same journal

Advances in tailored intraparenchymal delivery of regenerative medicine for spinal cord injury: a review of preclinical studies and clinical trials.

Neuro-Chirurgie·2026
Same journal

The renal involvement during lateral lumbar interbody fusion: a radioanatomical study for surgical risk stratification.

Neuro-Chirurgie·2026
Same journal

Chronic inflammatory involvement of the sacral multifidus insertion, predominantly observed after lumbar surgery.

Neuro-Chirurgie·2026
See all related articles

Related Experiment Video

Updated: Jun 8, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

[Local antitumor treatments].

P Menei1, P Metellus

  • 1Département de neurochirurgie, CHU d'Angers, 4, rue Larrey, 49940 Angers cedex 9, France. phmenei@chu-angers.fr

Neuro-Chirurgie
|September 28, 2010
PubMed
Summary
This summary is machine-generated.

Intraoperative adjuvant treatments for brain tumors are reviewed, focusing on phase III trials. Only Gliadel® is approved, while immunotoxins and gene therapy are in phase III trials; brachytherapy lacks clinical validation.

More Related Videos

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Related Experiment Videos

Last Updated: Jun 8, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Area of Science:

  • Neuro-oncology
  • Surgical oncology
  • Adjuvant therapies

Context:

  • Intraoperative adjuvant treatments aim to improve outcomes after primary tumor removal.
  • The review focuses on strategies rigorously evaluated in phase III clinical trials.

Purpose:

  • To review intraoperative adjuvant treatment strategies for brain tumors that have undergone phase III clinical trials.
  • To assess the current status and validation of various adjuvant therapies.

Summary:

  • Gliadel® is the only intraoperative adjuvant treatment strategy that has achieved marketing authorization.
  • Immunotoxins (convection-enhanced delivery) and adenovirus-mediated gene therapy are progressing through phase II/III trials.
  • Brachytherapy has not been validated through any clinical trials for this application.

Impact:

  • Highlights the limited success of intraoperative adjuvant therapies despite extensive research.
  • Identifies promising avenues like immunotoxins and gene therapy for future clinical development.
  • Underscores the need for robust clinical trial data, as exemplified by brachytherapy's lack of validation.