Rapid synthesis of 2',3'-dideoxy-3'β-fluoro-pyrimidine nucleosides from 2'-deoxypyrimidine nucleosides
Ahmed Khalil1, Christophe Mathé, Christian Périgaud
1Institut des Biomolécules Max Mousseron, UMR CNRS-UM, Université Montpellier, France.
Bioorganic Chemistry
|September 28, 2010
Abstract:
A rapid synthesis of 2',3'-dideoxy-3'-fluoro-β-D-threo-nucleosides bearing the pyrimidine canonical bases of nucleic acids has been developed in order to discover new nucleoside derivatives as potential antiviral drugs. However, when evaluated for their antiviral activity in cell culture experiments, none of these compounds showed any significant antiviral activity.
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