Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clean intermittent catheterization reverses hydronephrosis in a child with congenital nephrogenic diabetes insipidus: a case report.

The Canadian journal of urology·2026
Same author

LAR/NMLR stratify mortality risk before and after checkpoint inhibitor pneumonitis in NSCLC: multi-state and time-dependent analyses.

BMC cancer·2026
Same author

Novel 2-Phenyl-1H-Pyrrole Derivatives as Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss.

Chemical biology & drug design·2026
Same author

EGID: A Comprehensive Multi-label Endoscopic Image Dataset for Gastritis Classification.

Scientific data·2026
Same author

Simple 3D-printed stirred bioreactor enhances retinal organoid production via improved oxygenation.

Cell reports methods·2026
Same author

Discovery and evaluation of SIPI11594: a novel mitochondrial pyruvate carrier inhibitor with anti-hair loss efficacy.

Bioorganic & medicinal chemistry·2026

Related Experiment Video

Updated: Jun 8, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Fluorescent PLLA-nanodiamond composites for bone tissue engineering.

Qingwei Zhang1, Vadym N Mochalin, Ioannis Neitzel

  • 1Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, PA 19104, USA.

Biomaterials
|September 28, 2010
PubMed
Summary

This study developed a novel bone scaffold using poly(l-lactic acid) and nanodiamonds, significantly enhancing mechanical strength and biocompatibility. The resulting composite shows promise for bone tissue engineering and monitoring bone regeneration.

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Related Experiment Videos

Last Updated: Jun 8, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Tissue Engineering

Background:

  • Diamond nanoparticles offer superior mechanical properties, surface chemistry, and biocompatibility for biomaterial applications.
  • Biodegradable polymers like poly(l-lactic acid) (PLLA) are crucial for bone scaffold development.
  • Functionalized nanodiamonds can enhance polymer composite performance.

Purpose of the Study:

  • To create a multifunctional fluorescent composite bone scaffold material using PLLA and octadecylamine-functionalized nanodiamond (ND-ODA).
  • To evaluate the mechanical properties, biocompatibility, and potential applications of the developed ND-ODA/PLLA composite.
  • To explore the use of the composite's fluorescence for monitoring bone regeneration.

Main Methods:

  • Fabrication of ND-ODA/PLLA nanocomposite bone scaffolds.
  • Characterization of the composite's mechanical properties (hardness, Young's modulus).
  • In vitro testing of cell proliferation using murine osteoblast (7F2) cells.

Main Results:

  • Uniform dispersion of ND-ODA in PLLA significantly increased hardness and Young's modulus.
  • Addition of 10%wt ND-ODA improved Young's modulus by over 200% and hardness by 800%, approaching human cortical bone properties.
  • ND-ODA/PLLA composites demonstrated no negative effects on osteoblast cell proliferation.
  • The composite exhibited bright fluorescence suitable for monitoring applications.

Conclusions:

  • ND-ODA/PLLA composites offer enhanced mechanical properties, fluorescence, and drug delivery potential for bone scaffolds.
  • These materials are promising for musculoskeletal tissue engineering, regenerative medicine, and smart surgical tools.
  • The inherent fluorescence allows for in vivo monitoring of bone regrowth, potentially replacing implants.