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Updated: Jun 8, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
Interaction of human T-cell lymphotropic virus type I Rex protein with Dicer suppresses RNAi silencing
Makoto Abe1, Hitoshi Suzuki, Hironori Nishitsuji
1Department of Life and Environmental Sciences, Chiba Institute of Technology, Narashino, Chiba, Japan.
Abstract:
Double-stranded RNAs suppress the expression of homologous genes through an evolutionarily conserved process called RNA interference (RNAi) or post-transcriptional gene silencing. A bidentate nuclease called Dicer has been implicated as the protein responsible for the production of short interfering RNAs (siRNAs). In our experiments, Rex overexpression reduced the efficiency of short hairpin RNA (shRNA)-mediated RNAi. The interaction of Dicer with Rex inhibited the conversion of shRNA to siRNA. These results suggest that the interaction of Dicer with HTLV-I Rex inhibits Dicer activity and thereby reduces the efficiency of the conversion of shRNA to siRNA.
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