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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...

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Cost-Efficient Transcriptomic-Based Drug Screening
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Cost-Efficient Transcriptomic-Based Drug Screening

Published on: February 23, 2024

[Optimizing of cDNA preparation for next generation sequencing].

Qiao-Ping Qin1, Lan-Lan Zhang, Nan-Yi Li

  • 1School of Agriculture and Food Science, Zhejiang Agriculture and Forestry University, Lin'an 311300, China. qinqp@zafu.edu.cn

Yi Chuan = Hereditas
|September 28, 2010
PubMed
Summary
This summary is machine-generated.

This study introduces a DSN nuclease method to remove polyA sequences and enrich rare genes for large-scale sequencing. This technique improves sample preparation, enabling better gene discovery in genomic analysis.

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

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