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Related Experiment Video

Updated: Jun 8, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Liver Cancer Working Group report.

Masatoshi Kudo1, Kwang Hyub Han, Norihiro Kokudo

  • 1Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2, Ohono-Higashi, Osaka-Sayama, Osaka, Japan. m-kudo@med.kindai.ac.jp

Japanese Journal of Clinical Oncology
|September 28, 2010
PubMed
Summary

Hepatocellular carcinoma (HCC) is a major global health issue, particularly in Asia. While screening and new therapies like Sorafenib show promise, advanced stages and lack of effective treatments remain challenges.

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The Influence of Liver Resection on Intrahepatic Tumor Growth
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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The Influence of Liver Resection on Intrahepatic Tumor Growth
07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

Area of Science:

  • Hepatology
  • Oncology
  • Public Health

Background:

  • Hepatocellular carcinoma (HCC) is a leading cause of cancer death globally, especially in Asia, often linked to hepatitis B and C infections and liver cirrhosis.
  • Epidemiological patterns of HCC vary across Asia, with Japan exhibiting a profile similar to Western countries due to hepatitis C being a primary etiological factor.

Purpose of the Study:

  • To review the current landscape of hepatocellular carcinoma (HCC) epidemiology, diagnosis, and treatment in Asia.
  • To highlight the impact of vaccination programs, screening, and emerging therapies on HCC management.

Main Methods:

  • Review of epidemiological data on HCC incidence and etiological factors in Asian countries.
  • Analysis of the effectiveness of hepatitis B vaccination, cancer screening programs, and current treatment modalities.
  • Examination of advancements in diagnostic imaging and systemic therapies, including molecularly targeted agents.

Main Results:

  • Hepatitis B virus (HBV) vaccination programs are successfully reducing HBV-related HCC incidence.
  • Screening improves early detection but most Asian patients still present with advanced HCC, facing unsatisfactory long-term outcomes due to limited effective therapies.
  • Sorafenib is the first systemic therapy to show improved survival in advanced HCC; other targeted agents are under investigation.

Conclusions:

  • Despite progress in vaccination and screening, advanced HCC remains a significant challenge in Asia, necessitating improved systemic and adjuvant therapies.
  • Continuous updates to clinical practice guidelines are crucial to incorporate new evidence from evolving diagnostic and therapeutic techniques, including molecularly targeted therapies.