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Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
Published on: October 31, 2025
Gastric Cancer Working Group report.
Mitsuru Sasako1, Manami Inoue, Jaw-Town Lin
1Upper GI Surgery Division, Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. msasako@hyo-med.ac.jp
Japanese Journal of Clinical Oncology
|September 28, 2010
Summary
Gastric cancer, common in Asia, involves genetic factors, H. pylori, and environment. Prevention includes lifestyle changes and early screening. Treatment ranges from endoscopic resection to surgery and advanced chemotherapy.
Area of Science:
- Oncology
- Gastroenterology
- Public Health
Background:
- Gastric cancer is the second most prevalent cancer in Asia, with over half of global cases originating in East Asia.
- The majority of gastric cancer cases in Asia occur in the distal stomach.
- Key etiological factors include genetic predisposition, Helicobacter pylori infection, and environmental influences.
Purpose of the Study:
- To provide a comprehensive overview of gastric cancer epidemiology, etiology, prevention, diagnosis, and treatment.
- To highlight the role of screening and risk stratification in high-incidence regions.
- To discuss current and emerging therapeutic strategies for gastric cancer.
Main Methods:
- Review of epidemiological data on gastric cancer incidence and distribution in Asia.
- Summary of etiological factors and preventive measures, including lifestyle modifications and pharmacological interventions.
- Overview of diagnostic modalities such as endoscopy and risk stratification.
- Analysis of surgical approaches, including R0 resection and D2 lymph node dissection.
- Review of current chemotherapy regimens, targeted therapies, and ongoing research for advanced gastric cancer.
Main Results:
- Helicobacter pylori eradication, healthy diet, and NSAID use may reduce gastric cancer risk.
- Gastric cancer screening is cost-effective in high-incidence areas, with risk stratification improving efficiency in moderate-risk groups.
- Endoscopic resection offers curative potential for early-stage cancers.
- R0 resection combined with D2 lymph node dissection yields optimal survival outcomes.
- Post-operative adjuvant chemotherapy, particularly S-1, is recommended after D2 surgery.
- Fluorouracil plus platinum-based regimens are standard first-line chemotherapy, with taxanes or irinotecan for later lines.
- Trastuzumab is a standard treatment for HER2-positive gastric cancer.
- Numerous novel targeted agents are under investigation, with significant Asian contributions to research and development.
Conclusions:
- Gastric cancer management requires a multi-faceted approach encompassing prevention, early detection, and tailored treatment strategies.
- Advances in surgical techniques and adjuvant therapies have improved survival rates.
- Chemotherapy and targeted therapies continue to evolve, offering new hope for patients with advanced disease.
- Ongoing research, particularly in Asian countries, is crucial for developing more effective treatments for gastric cancer.
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