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Association of PTP1B gene polymorphism with obesity in Chinese children

Juan Mo1, Jing Wu, Zhixiang Sun

  • 1Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|September 28, 2010
PubMed

Insights

The protein tyrosine phosphatase 1B (PTP1B) gene Pro303Pro polymorphism is linked to childhood obesity in Chinese children, potentially impacting lipid metabolism. The IVS6+G82A polymorphism showed no significant association with childhood obesity.

Area of Science:

  • Genetics
  • Pediatrics
  • Metabolic Disorders

Background:

  • Childhood obesity is a growing global health concern with complex genetic and environmental factors.
  • Protein tyrosine phosphatase 1B (PTP1B) plays a crucial role in insulin signaling and energy homeostasis.
  • Genetic variations in the PTP1B gene may influence susceptibility to obesity.

Purpose of the Study:

  • To examine the distribution of PTP1B gene IVS6+G82A and Pro303Pro polymorphisms in Chinese children.
  • To determine the association between these PTP1B polymorphisms and the pathogenesis of childhood obesity.

Main Methods:

  • Genotyping of IVS6+G82A and Pro303Pro polymorphisms using PCR-RFLP in 147 obese and 118 healthy Chinese children.
  • Assessment of various anthropometric (WC, WHR, %BF) and metabolic parameters (SBP, DBP, FPG, TG, TC, HDL-C, LDL-C, FINS, HOMA-IR, leptin).

Main Results:

  • Significant differences in allele frequencies for the Pro303Pro polymorphism were observed between obese and healthy children.
  • The Pro303Pro polymorphism was associated with increased body mass index, waist circumference, triglycerides, and LDL-C in obese children.
  • No significant association was found for the IVS6+G82A polymorphism with childhood obesity or related clinical characteristics.

Conclusions:

  • The PTP1B gene Pro303Pro polymorphism may contribute to the pathogenesis of obesity in Chinese children.
  • This polymorphism might influence lipid metabolism in obese children, highlighting its potential role in metabolic dysregulation.
Abstract

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