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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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ADC changes in schizophrenia: a diffusion-weighted imaging study.

Igor Nenadic1, Gerd Wagner, Daniel Güllmar

  • 1Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany. igor.nenadic@uni-jena.de

European Archives of Psychiatry and Clinical Neuroscience
|September 28, 2010
PubMed
Summary
This summary is machine-generated.

This study found no significant changes in apparent diffusion coefficient (ADC) in schizophrenia patients, suggesting it

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Area of Science:

  • Neuroimaging
  • Psychiatric Disorders
  • White Matter Integrity

Background:

  • Diffusion Tensor Imaging (DTI) studies indicate reduced white matter anisotropy in schizophrenia.
  • Some DTI studies suggest alterations in apparent diffusion coefficient (ADC) in schizophrenia.

Purpose of the Study:

  • To investigate apparent diffusion coefficient (ADC) changes in the white matter of schizophrenia patients.
  • To determine if ADC is a reliable marker for white matter abnormalities in schizophrenia.

Main Methods:

  • Voxel-based analysis of ADC was performed on 18 schizophrenia patients and 18 healthy controls.
  • Multiple smoothing filter sizes were applied to assess the robustness of findings.

Main Results:

  • No statistically significant ADC changes were detected at P < 0.05 (FDR corrected).
  • A small increase in ADC was observed in a right prefrontal area at an uncorrected threshold (P < 0.001).
  • This finding was near a previously identified area of altered fractional anisotropy (FA).

Conclusions:

  • Apparent diffusion coefficient (ADC) changes do not appear to be a reliable marker for white matter or grey matter abnormalities in schizophrenia.
  • Fractional anisotropy (FA) may serve as a more sensitive indicator of white matter pathology in schizophrenia.