[Transient idiopathic hyperphosphatasemia in a rotavirus infection]
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Updated: Oct 16, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
1Reparto Pediatria, Laboratorio Analisi Cliniche, USL n. 13, Ospedale Civile, Licata.
Insights
Two siblings experienced temporary hyperphosphatasemia, a condition affecting alkaline phosphatase levels, linked to rotavirus infection. This transient elevation occurred without significant organ damage, suggesting a viral cause for this rare pediatric finding.
Area of Science:
- Pediatric Gastroenterology
- Clinical Biochemistry
- Virology
Background:
- Transitory hyperphosphatasemia is a rare condition characterized by temporary elevations in serum alkaline phosphatase.
- Idiopathic hyperphosphatasemia can occur in children, with its etiology often unclear.
- Previous studies have suggested potential links between viral infections and altered biochemical markers.
Abstract:
The paper reports two cases of transitory hyperphosphatasemia in two siblings of 13 and 29 months without modifications of the liver, kidney or bones. Laboratory data are given for hepatic and renal function and for the calcium/phosphorus metabolism. The paper underlines the observation of rotavirus and the consequent clinical symptoms in the two subjects. The hypothesised etiopathogenesis of transitory idiopathic hyperphosphatasemia is referred to a viral mechanism, and to rotavirus in particular.
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