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Published on: November 17, 2018
Thyroid hormone receptor and lipid regulation.
1The Methodist Hospital Research Institute, Center for Diabetes Research, Houston, TX 77030, USA. pwebb@tmhs.org
Current Opinion in Investigational Drugs (London, England : 2000)
|September 28, 2010
Summary
Scientists are developing thyroid hormone (TH) analogs to lower lipids without harmful side effects. Recent advances focus on TRβ-selective modulators, with early clinical trials showing promise for eprotirome.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Pharmacology
Background:
- Thyroid hormone (TH) analogs aim to leverage beneficial lipid-lowering effects while mitigating adverse impacts on cardiovascular, muscular, and skeletal systems.
- Decades of research have sought selective TH receptor (TR) modulators (STRMs) for safe lipid reduction, but previous attempts have consistently failed.
Purpose of the Study:
- To review recent progress in developing TRβ subtype- and liver-selective STRM analogs.
- To present preliminary clinical trial data for eprotirome (KB-2115).
Main Methods:
- Review of recent scientific literature on TRβ-selective STRMs.
- Analysis of preliminary clinical trial results for eprotirome.
Main Results:
- Recent advances have been made in creating TRβ subtype- and liver-selective STRM analogs.
- Preliminary clinical trials of eprotirome (KB-2115) have been conducted.
Conclusions:
- Selective TRβ- and liver-targeting STRMs represent a promising new avenue for TH analog development.
- Eprotirome shows potential in early clinical evaluation for safe lipid management.
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