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Updated: Jun 8, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
[Oxidative stress induced by peroxynitrite]
1Instytut Techniki Radiacyjnej, Wydzial Chemiczny, Politechnika Łódzka, Łódź. lgebicka@mitr.p.lodz.pl
Abstract:
Peroxynitrite which is formed in vivo under oxidative stress in a diffusion-controlled reaction between *NO and O2*- is a strong oxidizingand nitrating agent. It has been suggested that peroxynitrite is involved in the development of a variety of pathological conditions including diabetes, cardiovascular and neurodegenerative disorders. Several physiological routes for peroxynitrite decomposition have been found up to date. Among natural catalytical scavengers of peroxynitrite are peroxiredoxins, catalase, some peroxidases, methemoglobin and myoglobin. Reactions with synthetic perxynitite scavengers have been also studied. Successful results have been obtained for Mn(II), Mn(III) and Fe(III)-porphyrin.
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