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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Endophthalmitis caused by Stenotrophomonas maltophilia
Kuan-Jen Chen1, Nan-Kai Wang, Ming-Hui Sun
1Department of Ophthalmology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan. cgr999chiayi@yahoo.com.tw
Background And Objective:
The authors investigate clinical settings, antibiotic susceptibility and resistance patterns, and visual outcomes associated with endophthalmitis caused by Stenotrophomonas maltophilia.
Patients And Methods:
Records of six patients with S. maltophilia endophthalmitis between January 1, 1998, and December 31, 2007, were reviewed.
Results:
Clinical settings included post-trauma (2 eyes), post-cataract extraction (2 eyes), post-keratoplasty with keratitis (1 eye), and post-vitreous lavage (1 eye). Presenting visual acuity ranged from counting fingers to no light perception. Final visual acuity ranged from 10/20 to no light perception. Initial treatment included pars plana vitrectomy in 4 eyes and tap in 2 eyes. Most isolates were susceptible to fluoroquinolones (ciprofloxacin, levofloxacin, or moxifloxacin) and sulfamethoxazole-trimethoprim; however, they were resistant to ceftazidime and aminoglycosides.
Conclusion:
S. maltophilia is an uncommon causative agent of endophthalmitis and is resistant to commonly used antibiotics, such as ceftazidime and aminoglycosides. Based on in vitro antibiotic susceptibility testing, sulfamethoxazole-trimethoprim and new-generation fluoroquinolones may be preferable in the treatment of endophthalmitis caused by S. maltophilia.
Insights
Stenotrophomonas maltophilia endophthalmitis is rare and resistant to common antibiotics. Sulfamethoxazole-trimethoprim and newer fluoroquinolones show promise for treating this infection.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Investigates clinical settings, antibiotic susceptibility, and visual outcomes of Stenotrophomonas maltophilia endophthalmitis.
- S. maltophilia is an uncommon cause of endophthalmitis.
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