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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

The current landscape and unmet needs in multiple sclerosis.

Clyde E Markowitz¹

¹Multiple Sclerosis Center, University of Pennsylvania, 3400 Spruce St, 3 W Gates Bldg, Philadelphia, PA 19104, USA. cmarkowi@mail.med.upenn.edu

The American Journal of Managed Care

|September 30, 2010

Summary

New multiple sclerosis (MS) therapies offer improved efficacy and oral administration, potentially enhancing treatment adherence. Research is shifting towards sustained disease inactivity and neuroprotection, utilizing advanced imaging and understanding of MS pathophysiology.

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Area of Science:

Neurology and Pharmacology
Immunology and Disease Pathophysiology

Background:

First-line multiple sclerosis (MS) treatments (interferon beta-1a, interferon beta-1b, glatiramer acetate) introduced in the 1990s advanced care but had limitations.
These therapies, while delaying progression, did not prevent it in most patients and required frequent injections, impacting treatment adherence.
The long-term safety and tolerability of newer, highly effective MS therapies remain largely unknown.

Purpose of the Study:

To review the evolution of multiple sclerosis pharmacologic therapies.
To discuss the limitations of current treatments and the potential of new therapeutic agents.
To highlight advancements in MS research, including new outcome measures and understanding of disease mechanisms.

Main Methods:

Review of existing literature on multiple sclerosis pharmacologic treatments.
Analysis of the efficacy, administration routes, and adherence challenges of first-line and newer MS therapies.
Discussion of emerging research in MS pathophysiology, neuroprotection, and outcome measurement techniques.

Main Results:

Newer MS therapies demonstrate impressive efficacy, with oral formulations potentially improving treatment adherence.
The concept of sustained disease inactivity is emerging as a treatment goal, challenging the notion of inevitable progression.
Advances in imaging (e.g., "black holes") and understanding of MS pathophysiology (neurotrophic factors, oxidative stress) are refining efficacy assessment and drug development.

Conclusions:

A new generation of MS therapies offers enhanced efficacy and improved administration routes.
The treatment paradigm for MS is shifting towards achieving sustained disease inactivity and exploring neuroprotective strategies.
Ongoing research into MS pathophysiology and advanced imaging techniques are crucial for developing and measuring the effectiveness of future treatments.