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Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord
10:44

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Published on: February 22, 2015

Emerging oral agents for multiple sclerosis.

Edward J Fox1

  • 1Central Texas Neurology Consultants, 16040 Park Valley Dr, Bldg B, Ste 100, Round Rock, TX 78681, USA. foxtexms@gmail.com

The American Journal of Managed Care
|September 30, 2010
PubMed
Summary
This summary is machine-generated.

Emerging oral therapies for multiple sclerosis (MS) show promise for improved efficacy and adherence. Cladribine, laquinimod, and fingolimod demonstrate strong clinical and MRI results, while dalfampridine improves walking in MS patients.

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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

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Published on: September 12, 2016

Area of Science:

  • Neurology
  • Immunology
  • Pharmacology

Background:

  • Multiple sclerosis (MS) treatments are evolving with new oral therapies.
  • Existing MS therapies often require injections, potentially impacting patient adherence.
  • Novel oral agents offer different mechanisms of action and potentially enhanced efficacy.

Purpose of the Study:

  • To review emerging oral therapies for multiple sclerosis.
  • To analyze the mechanisms of action, efficacy, and safety of cladribine, laquinimod, fingolimod, and dalfampridine.
  • To compare these novel agents with existing first-line MS treatments.

Main Methods:

  • Review of clinical trial data and FDA-approved information.
  • Analysis of efficacy based on clinical outcomes (relapse rates, disability scores) and MRI variables.
  • Assessment of safety and tolerability profiles of the discussed agents.

Main Results:

  • Cladribine, laquinimod, and fingolimod show significant efficacy in clinical and MRI outcomes.
  • Dalfampridine is FDA-approved for symptomatic treatment to improve walking in MS patients.
  • These emerging therapies generally present tolerable side-effect profiles in current data.

Conclusions:

  • New oral therapies for MS, including cladribine, laquinimod, and fingolimod, offer promising efficacy and improved adherence potential.
  • Dalfampridine provides a valuable symptomatic treatment option for MS-related walking impairment.
  • Long-term safety data is crucial to determine the role of these agents against existing MS therapies.