Related Experiment Video
Updated: Jun 8, 2026

Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
Published on: June 2, 2023
The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic
Joseph Geradts1, Sarah M Bean, Rex C Bentley
1Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA. joseph.geradts@duke.edu
Abstract:
In a series of 177 breast carcinomas, we found that the Oncotype DX Recurrence Score (RS) was correlated with six pathobiologic features: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status, and the three components of the Nottingham tumor grade. The RS also correlated with a composite index (the Breast Cancer Prognostic Score or BCPS) comprising the same six parameters. Categorical concordance was 56% and 66% using conventional and TAILORx cutoffs, respectively. Our data show that a composite prognostic index can be constructed from routinely reported breast tumor features that captures much of the information provided by the Oncotype assay at no added cost.
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