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Updated: Jun 8, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Prognostic value of E-cadherin expression and CDH1 promoter methylation in patients with endometrial carcinoma
Tie-Zhong Yi1, Jing Guo, Lili Zhou
1Department of Obstetrics and Gynecology, the First Affiliated Hospital, Harbin Medical University, Harbin, China.
Abstract:
The primary aim of this study is to evaluate the clinical significance of E-cadherin protein expression and the methylation status in CDH1 promoter in endometrial cancer. The expression of E-cadherin and methylation in its promoter region was analyzed, retrospectively, in 152 clinical tissue samples from patients with endometrial lesions. We found that the hypermethylation of CDH1 promoter, which caused low expression of E-cadherin in endometrial cancer, was associated with not only clinicopathological progress of endometrial cancer but also with the overall 5-year clinical survival rate. The findings provide the potential therapeutic and prognostic target molecule for patients with endomethrial cancer.
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