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Related Experiment Videos

[Change of renal function immediately after angiography].

K Gemma1, H Tajima, K Ito

  • 1Department of Radiology, Nippon Medical School.

Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica
|November 25, 1990
PubMed
Summary

Abdominal angiography with low osmolality contrast material caused increased fractional excretion of sodium (FENa) in patients with normal renal function. This suggests osmotic diuresis and proximal tubular stress.

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Area of Science:

  • Nephrology
  • Radiology
  • Pharmacology

Context:

  • Abdominal angiography is a common diagnostic procedure.
  • Ioxaglate is a low osmolality contrast material used in angiography.
  • Renal function is crucial for evaluating the impact of contrast agents.

Purpose:

  • To investigate the renal effects of low osmolality contrast material during abdominal angiography.
  • To compare renal parameters before and after the procedure.
  • To assess potential tubular stress induced by the contrast agent.

Summary:

  • Abdominal angiography was performed on 10 patients with normal renal function using ioxaglate (3.0-4.5 ml/kg).
  • Renal parameters including creatinine clearance (Ccr), fractional excretion of sodium (FENa), and free water clearance (CH2O) were measured before and immediately after angiography.

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  • While Ccr and CH2O showed no significant changes, FENa increased significantly post-angiography, indicating osmotic diuresis and proximal tubular stress.

    • Impact:

    • The study highlights the potential for contrast-induced nephropathy, even with low osmolality agents.
    • Findings suggest careful patient selection and monitoring are necessary for individuals undergoing abdominal angiography.
    • This research contributes to understanding the physiological impact of iodinated contrast media on renal function.