Role of phenolic compounds in nitric oxide synthase activity in colon and breast adenocarcinoma

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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Didem Turgut Cosan1, Banu Bayram, Ahu Soyocak

  • 1Department of Medical Biology, Medical Faculty, Eskişehir Osmangazi University, Eskişehir, Turkey. dcosan@gmail.com

Cancer Biotherapy & Radiopharmaceuticals
|September 30, 2010
PubMed

Insights

Resveratrol (RES) and tannic acid (TA) show potential as cancer chemopreventive agents by decreasing nitric oxide synthase (NOS) activity in colon and breast cancer cells.

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Cancer chemoprevention strategies aim to inhibit tumorigenesis.
  • Nitric oxide synthase (NOS) plays a role in cancer development.
  • Resveratrol (RES) and tannic acid (TA) are studied for their chemopreventive properties.

Purpose of the Study:

  • To investigate the effects of RES and TA on NOS levels.
  • To determine the impact of these agents on colon and breast cancer cell lines.

Main Methods:

  • Utilized CaCo-2 (colon) and MCF-7 (breast) cancer cell lines.
  • Treated cells with RES and TA.
  • Measured nitric oxide synthase (NOS) enzyme activity using a specific assay kit.
  • Analyzed data using Student's t-test.

Main Results:

  • A general decrease in nitric oxide (NO) activity was observed in both CaCo-2 and MCF-7 cells treated with RES and TA.
  • RES and TA demonstrated varying effects on NOS enzyme activity across the different cancer cell types.

Conclusions:

  • The phenolic compounds RES and TA may modulate NOS activity in cancer cells.
  • These findings suggest a potential role for RES and TA in colon and breast cancer chemoprevention through their influence on NOS.

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