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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer is an enzyme that can...
Heterochromatin02:38

Heterochromatin

The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...

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Related Experiment Video

Updated: Jun 8, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Stringent programming of DNA methylation in humans.

Hnin T Aung1, Dion K Harrison, Ian Findlay

  • 1School of Chemistry and Molecular Biosciences, The University of Queensland, Australia.

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
|September 30, 2010
PubMed
Summary
This summary is machine-generated.

Amplified Methylation Polymorphism (AMP) is a new PCR-based method to scan genomes for DNA methylation changes. This technique identifies tissue-specific methylation patterns, showing identical profiles in healthy twins.

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Last Updated: Jun 8, 2026

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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

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Area of Science:

  • Genomics
  • Epigenetics
  • Molecular Biology

Background:

  • DNA methylation is crucial for gene regulation and cellular function.
  • Aberrant DNA methylation patterns are linked to various diseases.
  • Detecting methylation changes is essential for understanding biological processes.

Purpose of the Study:

  • To introduce a novel PCR-based method, Amplified Methylation Polymorphism (AMP), for genome-wide DNA methylation analysis.
  • To characterize tissue-specific DNA methylation signatures.
  • To assess the utility of AMP in comparing methylation profiles.

Main Methods:

  • Developed and applied Amplified Methylation Polymorphism (AMP), a PCR-based technique.
  • Focused on detecting DNA methylation changes at specific genomic locations.
  • Analyzed methylation profiles in relation to intron-exon junctions and CpG islands.

Main Results:

  • AMP successfully scans genomes for DNA methylation alterations.
  • Identified tissue-specific DNA methylation signatures.
  • Observed identical AMP profiles in healthy, young, monozygotic twins, indicating high reproducibility and sensitivity.

Conclusions:

  • Amplified Methylation Polymorphism (AMP) is an effective tool for detecting DNA methylation changes.
  • The method can reveal tissue-specific epigenetic patterns.
  • AMP shows promise for comparative epigenomic studies and twin research.