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Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol
Published on: September 21, 2021
Targeting tryptophan hydroxylase 2 in affective disorder
Nina K Popova1, Alexander V Kulikov
1Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia. npopova@bionet.nsc.ru
Expert Opinion on Therapeutic Targets
|September 30, 2010
Summary
Tryptophan hydroxylase 2 (TPH2) gene variations are linked to behavioral changes and affective disorder risk. Further genetic studies are needed to enhance TPH2
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Serotonin (5-HT) is crucial in psychiatric disorders like schizophrenia and depression.
- Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in serotonin synthesis.
Purpose of the Study:
- To review the association between TPH2 and affective disorders.
- To explore TPH2's potential as a clinical target.
Main Methods:
- Review of TPH2's role in 5-HT-dependent behavior.
- Analysis of TPH2 gene polymorphism and human behavior.
- Examination of TPH2's link to antidepressant sensitivity.
- Assessment of dietary tryptophan effects on affective behavior.
Main Results:
- TPH2 is associated with genetically defined behavioral variations.
- TPH2 gene variations (SNPs, haplotypes) can predict affective disorder risk and antidepressant response.
- Reduced TPH2 activity negatively impacts behavior and potentially survival.
- Dietary tryptophan manipulation has a modest effect on mood compared to standard antidepressants.
Conclusions:
- Comprehensive TPH2 genetics research is essential.
- Enhancing the clinical utility of TPH2 as a biomarker for affective disorder risk and antidepressant efficacy requires further study.
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