Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Classification of Epithelial Tissues: Overview

Classification of Epithelial Tissues: Overview

Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Strengthening Biomarker Research in Canadian Cancer Clinical Trials: A Pathology-Focused White Paper.

Current oncology (Toronto, Ont.)·2026

Same author

Somatic mutations distinguish melanocyte subpopulations in human skin.

Nature cell biology·2026

Same author

The impact of next generation sequencing studies on the diagnosis of BAP1 inactivated melanocytic tumors.

Human pathology·2026

Same author

FGD1 guanine nucleotide exchange factor drives secondary resistance to BRAF inhibition in melanoma.

Melanoma research·2026

Same author

Prospective multicenter study of ctDNA versus tumor tissue guiding FGFR-targeted therapy in metastatic urothelial cancer.

Nature communications·2026

Same author

Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma.

Nature communications·2025

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Genetic and morphologic features for melanoma classification.

Sigrid M C Broekaert¹, Ritu Roy, Ichiro Okamoto

¹Department of Dermatology, University of California San Francisco, 1701 Divisadero St, San Francisco, CA 94115, USA.

Pigment Cell & Melanoma Research

|September 30, 2010

Summary

This summary is machine-generated.

This study validates melanoma subtype associations between genetic mutations (BRAF, NRAS) and histomorphologic features. Findings support refined classification for biologically distinct melanoma groups.

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Related Experiment Videos

Last Updated: Jun 8, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Area of Science:

Oncology
Dermatopathology
Cancer Genetics

Background:

Melanoma comprises distinct biological subtypes with incompletely defined clinical, histomorphologic, and molecular features.
Understanding these features is crucial for accurate classification and patient management.

Purpose of the Study:

To validate previously described associations between genetic (BRAF, NRAS) and histomorphologic features in primary cutaneous melanoma.
To assess the reproducibility of these histomorphologic features.
To determine the association of these features with clinical variables, including metastasis.

Main Methods:

Detailed clinical and histomorphologic assessment of 365 primary cutaneous melanomas by 11 pathologists.
Correlation of histomorphologic features with BRAF and NRAS mutation status.
Analysis of interobserver reproducibility for quantitative histomorphologic assessments.

Main Results:

Substantial agreement was observed in quantitative histomorphologic feature assessment, exceeding the reproducibility of the World Health Organization classification.
Melanomas with BRAF mutations exhibited characteristic morphologic features (P < 0.0001) and higher rates of regional lymph node metastasis (P = 0.046).
A subset of melanomas without mutations showed clinical and morphological similarities to BRAF-mutated melanomas, suggesting potential biological relationships.

Conclusions:

The study confirms significant associations between histomorphologic features, mutation status (BRAF, NRAS), and metastatic patterns in melanoma.
These findings provide criteria for a refined melanoma classification system.
The proposed classification aims to define biologically homogeneous disease subgroups for improved understanding and treatment.