Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Piezoelectric scaffolds for bone regeneration: a systematic review of preclinical studies.

Frontiers in bioengineering and biotechnology·2026
Same author

Regulatory Frameworks and Clinical Development of Orthobiologics Across Asia and Europe.

The Journal of bone and joint surgery. American volume·2026
Same author

Orthobiologics at a Crossroads: From Biological Promise to Evidence-Based Orthopaedic Practice.

The Journal of bone and joint surgery. American volume·2026
Same author

Bibliometric analysis of enthesis research: a comprehensive review from 1999 to 2024.

International orthopaedics·2026
Same author

Talazoparib engages innate immune activation via PARP trapping-dependent cGAS/STING activation in Ewing Sarcoma.

Cancer letters·2026
Same author

Are orthobiologics a plausible therapeutic option for patello-femoral pathology? A systematic review of clinical and radiological outcomes.

Frontiers in bioengineering and biotechnology·2026

Related Experiment Video

Updated: Jun 8, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite

Elizaveta Kon1, Giuseppe Filardo, Marco Delcogliano

  • 1Biomechanics Laboratory-Rizzoli Orthopaedic Institute, Bologna, Italy. e.kon@biomec.ior.it

BMC Musculoskeletal Disorders
|September 30, 2010
PubMed
Summary

A hydroxyapatite-collagen scaffold improved osteochondral defect repair in sheep. Adding platelet-rich plasma (PRP) to the scaffold hindered bone and cartilage regeneration, negatively impacting healing.

More Related Videos

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Related Experiment Videos

Last Updated: Jun 8, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Developing effective strategies for chondral and osteochondral regeneration is crucial.
  • Platelet-rich plasma (PRP) is explored for its potential to enhance tissue repair.
  • This study evaluates PRP's effect on a novel collagen-hydroxyapatite scaffold for osteochondral defects.

Purpose of the Study:

  • To investigate the regenerative potential of platelet-rich plasma (PRP).
  • To assess PRP's efficacy in enhancing a collagen-hydroxyapatite scaffold for osteochondral defect repair in a sheep model.

Main Methods:

  • A multi-layer gradient nanocomposite scaffold was created using collagen fibrils and hydroxyapatite nanoparticles.
  • Osteochondral lesions were surgically created in sheep femoral condyles.
  • Animals were randomized into three groups: scaffold only, scaffold with autologous PRP, and control (empty defect).

Main Results:

  • Both scaffold groups showed good chondral integration, but the scaffold alone yielded significantly better bone regeneration and cartilage surface reconstruction.
  • The scaffold with PRP exhibited incomplete bone regeneration and irregular cartilage integration.
  • Control defects filled with fibrous tissue, showing no healing.

Conclusions:

  • The hydroxyapatite-collagen scaffold effectively enhanced osteochondral lesion repair.
  • Platelet-rich plasma (PRP) did not provide an additive benefit and negatively impacted regeneration by disrupting the healing process.
  • PRP combined with the scaffold resulted in disorganized cartilaginous repair tissue and poorly organized bone tissue.