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Updated: Jun 8, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Hepatitis E virus genotype diversity in eastern China.

Wen Zhang¹, Yilin He, Hua Wang

¹School of Medical Science and Laboratory Medicine, Jiangsu University, Jiangsu, People's Republic of China. z0216wen@yahoo.com

Emerging Infectious Diseases

|September 30, 2010

Summary

This summary is machine-generated.

Hepatitis E virus (HEV) genotypes 1, 3, and 4 were found in Chinese patients. Genotype 3 and subgenotype 4b in humans were linked to swine strains, suggesting zoonotic HEV genotype 3 transmission in China.

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Last Updated: Jun 8, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

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Published on: June 26, 2020

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Area of Science:

Virology
Infectious Diseases
Public Health

Background:

Hepatitis E virus (HEV) is a significant global health concern.
Understanding HEV genotypes and transmission routes is crucial for disease control.

Purpose of the Study:

To investigate the prevalent HEV genotypes in hospitalized patients in Nanjing and Taizhou, China.
To explore the genetic relationship between human and swine HEV strains in the region.

Main Methods:

Analysis of 47 HEV isolates from hospitalized patients.
Genotyping of HEV isolates.
Phylogenetic analysis to compare human and swine HEV strains.

Main Results:

Genotypes 1, 3, and 4 were identified as prevalent in the studied population.
HEV genotype 3 and subgenotype 4b isolates from humans showed a close genetic relationship with swine HEV strains from eastern China.

Conclusions:

The findings suggest that HEV genotype 3 in humans in China likely originated from swine.
This highlights the potential for zoonotic transmission of HEV genotype 3.