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Updated: Jun 8, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

A 3-month-old with a blistering plaque.

Ali Alsharqi¹, Richard Parslew, Rajeev Shukla

¹The Royal Liverpool and Broadgreen University Hospitals NHS Trust.

Dermatology Online Journal

|September 30, 2010

Summary

Pediatric cutaneous mastocytosis can mimic bullous impetigo. A solitary mastocytoma presented as a blister in an infant, highlighting the need to consider rare diagnoses beyond common infections.

Area of Science:

Pediatric Dermatology
Dermatopathology

Background:

Cutaneous mastocytosis is a diverse group of disorders characterized by the abnormal proliferation of mast cells in the skin.
While urticaria pigmentosa is the most common form, other presentations exist, particularly in infants.

Observation:

A 3-month-old infant presented with a solitary skin lesion resembling a blister.
The initial clinical diagnosis was recurrent bullous impetigo, supported by a positive skin swab culture.

Findings:

Histopathological examination confirmed the lesion as a solitary mastocytoma, a rare presentation of cutaneous mastocytosis.
The blistering nature of the lesion mimicked bacterial infections, leading to a potential misdiagnosis.

Implications:

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This case underscores the importance of considering cutaneous mastocytosis in the differential diagnosis of blistering lesions in infants, even with signs suggestive of infection.

Clinicians must be aware that infections like bullous impetigo can secondarily affect other primary skin conditions.

Early and accurate diagnosis of solitary mastocytoma is crucial to rule out systemic involvement and guide appropriate management.