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Population pharmacokinetics study of azithromycin oral formulations using NONMEM
1College of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
Objective:
A population pharmacokinetic study of orally dosed azithromycin was conducted in order to determine if the antibiotic usage in clinical practice is reasonable and individualized.
Method:
A nonlinear mixed effect model with various oral azithromycin formulations was constructed using the NONMEM program. Based on a dataset of 160 healthy volunteers, the pharmacokinetic parameters and the relationship between the inter-individual effects and fixed effects were estimated.
Result:
A two compartment model with first-order absorption and elimination was established. The values for Cl1/F, Cl2/F, V1/F, V2/F and Ka were 121 ml/h, 282 ml/h, 1,939 ml, 5,650 ml and 1.05 h-1, respectively. The results provided evidence that the body weight affects the Cl1/F and Cl2/F and age affects the V1/F.
Conclusion:
A nonlinear mixed effect model for oral azithromycin formulations was developed for a Chinese healthy population.
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