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Published on: November 10, 2014
Upper aerodigestive tract lymphoma in Taiwan
Shang-Wen Chen1, Sheng-Tsung Chang, Chin-Li Lu
1Division of Hemato-Oncology, Department of Internal Medicine, Chi-Mei Medical Centre, Liouying, Tainan, Taiwan.
Journal of Clinical Pathology
|September 30, 2010
Summary
This study on upper aerodigestive tract lymphomas found that raised lactate dehydrogenase (LDH) at diagnosis is the only significant prognostic factor. Epstein-Barr virus (EBV) positivity was noted in diffuse large B cell lymphomas (DLBCLs).
Area of Science:
- Oncology
- Pathology
- Immunology
Background:
- Extranodal lymphoma frequently occurs in the upper aerodigestive tract.
- Understanding the spectrum of primary lymphomas in this region is crucial for diagnosis and treatment.
Purpose of the Study:
- To characterize the spectrum of primary lymphomas in the upper aerodigestive tract.
- To identify prognostic factors for lymphoma in this anatomical region.
Main Methods:
- Retrospective analysis of lymphoma cases diagnosed between 1992 and 2007 in southern Taiwan.
- Involved pathology review, immunohistochemistry, and Epstein-Barr virus in situ hybridization (EBER-ISH).
- Statistical analysis including univariate and multivariate analyses for prognostic factors.
Main Results:
- 70 patients were identified, with a male to female ratio of 2:1 and median age of 61.5 years.
- B cell lymphomas (64%) predominated, with diffuse large B cell lymphomas (DLBCLs) being the most common type (60%).
- Raised lactate dehydrogenase (LDH) was the only significant prognostic factor for lymphoma-related death on multivariate analysis.
Conclusions:
- The upper aerodigestive tract harbors a limited spectrum of primary lymphomas.
- Raised LDH at diagnosis is a key prognostic indicator.
- A notable incidence of Epstein-Barr virus (EBV) positivity in DLBCLs warrants further investigation.
