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Bioindicators in the MIDUS national study: protocol, measures, sample, and comparative context.

Gayle Dienberg Love¹, Teresa E Seeman, Maxine Weinstein

¹Institute on Aging, 2245 Medical Sciences Center, University of Wisconsin, Madison 53706, USA. glove@wisc.edu

Journal of Aging and Health

|September 30, 2010

Summary

The Midlife in the United States (MIDUS) study collected biological data from participants aged 35-85. This research provides a valuable resource for understanding health and aging by linking biological factors with survey data.

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Area of Science:

Gerontology
Public Health
Biomedical Research

Background:

The Midlife in the United States (MIDUS) study is a national longitudinal survey examining health and aging.
It includes individuals aged 25-74 at baseline, with subsequent biological assessments on a subsample.

Purpose of the Study:

To describe the protocol, measures, and sample for public use.
To facilitate research on health and aging by linking biological data with existing survey content.

Main Methods:

A 2-day clinical data-collection protocol was administered to a subsample of MIDUS respondents (aged 35-85).
Procedures included fasting blood and urine specimens, medical history, physical examination, bone densitometry, and physiological challenge tests (e.g., heart rate variability, salivary cortisol).

Main Results:

The biological protocol achieved response rates of 39.3% to 43.1% (N=1,255).
Non-participation was primarily due to logistical and personal constraints.
Respondents in the biological subsample were comparable to the overall recruitment pool in demographics and health.

Conclusions:

The MIDUS biological protocol offers a robust dataset for studying health and aging.
Its strength lies in the ability to integrate biological measures with extensive survey data from other MIDUS projects.