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Related Concept Videos

Assessing the Angiogenesis Effects of a Test Drug in a Rat Model of Ischemic Stroke01:18

Assessing the Angiogenesis Effects of a Test Drug in a Rat Model of Ischemic Stroke

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Begin with a rat subjected to middle cerebral artery occlusion, a surgical procedure that temporarily blocks blood flow to the brain tissue.This induces an ischemic stroke, leading to brain tissue damage.Next, remove the blockage to restore blood flow.Select rats that exhibit neurological deficits to ensure study relevance.Then, administer the test drug to the experimental group while injecting saline into the other group.Repeat the drug and saline administration.The test drug promotes...
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Rat in vivo models are indispensable tools to investigate the pathological mechanisms and therapeutic targets for ischemic stroke. This work will describe performing immunofluorescence staining in infarcted brain slices following middle cerebral artery occlusion (MCAO) in...
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Here, we present a protocol to establish a distal middle cerebral artery occlusion (dMCAO) model through transcranial electrocoagulation in C57BL/6J mice and evaluate the subsequent neurological behavior and histopathological...
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Positron Emission Tomography (PET) imaging of translocator protein 18 kDa (TSPO) provides a non-invasive means to visualize the dynamic role of neuroinflammation in the development and progression of brain diseases. This protocol describes TSPO-PET and ex vivo autoradiography to detect neuroinflammation in a mouse model of ischemic...
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The outcome of patients with acute ischemic stroke depends on swift restoration of cerebral blood flow. This protocol aims at optimizing the management of such patients by minimizing peri-procedural timings and rendering the time from hospital admission to reperfusion as short as...
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In this paper, we demonstrate a standard method for producing an embolic middle cerebral artery occlusion with homologous blood clots (fibrin-rich) in adult rat. This model closely mimics human ischemic stroke and is suitable for preclinical study of thrombolytic therapy for ischemic stroke.
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Related Experiment Video

Updated: Jan 20, 2026

Assessing the Angiogenesis Effects of a Test Drug in a Rat Model of Ischemic Stroke
01:18

Assessing the Angiogenesis Effects of a Test Drug in a Rat Model of Ischemic Stroke

Published on: August 6, 2025

91

Plasminogen activators in ischemic stroke: introduction

Gregory J del Zoppo1

  • 1Department of Medicine, University of Washington School of Medicine, Box 359756, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA. grgdlzop@u.washington.edu

Stroke
|September 30, 2010
PubMed
Summary

No abstract available in PubMed .

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