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Related Experiment Video

Updated: Jun 8, 2026

Prehospital Thrombolysis: A Manual from Berlin

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Thrombolysis with plasmin: implications for stroke treatment.

Victor J Marder¹, Reza Jahan, Theresa Gruber

¹Division of Hematology-Oncology, David Geffen School of Medicine at University of California Los Angeles, Room A3-29 Rehabilitation Building, 1000 Veteran Ave, Los Angeles, CA 90095, USA. vmarder@mednet.ucla.edu

|September 30, 2010

Summary

Plasmin, a direct-acting thrombolytic, shows superior safety and efficacy in dissolving blood clots. This study demonstrates plasmin

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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

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Published on: August 18, 2015

Area of Science:

Biomedical research
Cardiovascular science
Neurology

Background:

Plasminogen activators carry a risk of bleeding at effective thrombolytic doses.
Plasmin, a direct-acting thrombolytic, demonstrates a significant hemostatic safety advantage in preclinical models.
Previous trials indicate plasmin is safe for peripheral arterial occlusion, prompting investigation for stroke therapy.

Purpose of the Study:

To evaluate the efficacy of plasmin in inducing recanalization in a rabbit model of middle cerebral artery occlusion.
To establish a dose-ranging study for plasmin delivery via catheter in acute ischemic stroke models.

Main Methods:

A rabbit model of middle cerebral artery occlusion was induced using thrombin.
Angiography was used to document vascular patency and recanalization.
A dose-ranging study of plasmin (1-3 mg) delivered via catheter over 10 minutes was performed.

Main Results:

Plasmin induced rapid recanalization within 10 minutes in all treated rabbits across all tested doses.
Control saline infusion failed to achieve recanalization in the control group.
Plasmin demonstrated dose-dependent efficacy in restoring blood flow in the occluded artery.

Conclusions:

Plasmin rapidly induces recanalization of the middle cerebral artery in an established animal model.
These findings support the initiation of a Phase I/IIa clinical trial for plasmin in human ischemic stroke.
Plasmin represents a promising therapeutic agent for acute ischemic stroke due to its rapid action and safety profile.