Related Experiment Video
Updated: Jun 8, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Therapeutic hypothermia for brain ischemia: where have we come and where do we go?
Midori A Yenari1, Thomas M Hemmen
1Department of Neurology, University of California, San Francisco, CA 94121, USA. yenari@alum.mit.edu
Abstract:
Mild hypothermia is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of brain injury. At the clinical level, mild hypothermia has shown benefits in patients who have experienced cardiac arrest and in some pediatric populations experiencing hypoxic brain insults. Its role, however, in stroke therapy has yet to be established. Translating preclinical data to the clinical arena presents unique challenges with regard to cooling in patients who are generally awake and may require additional therapies, such as reperfusion. We review the state of therapeutic hypothermia in ischemic and hemorrhagic stroke and provide an outlook for its role in stroke therapy.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Decreased Body Temperature
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Ischemic Stroke l: Introduction

