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Related Experiment Video

Updated: Jun 8, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Acral lentiginous melanoma.

S Khandpur¹, B S N Reddy

¹Department of Dermatology, STD and Leprology, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi - 110 002, India.

Indian Journal of Dermatology, Venereology and Leprology

|September 30, 2010

Summary

A patient with advanced acral lentiginous melanoma experienced reduced lymph node metastasis after chemotherapy. However, the primary sole lesion showed no improvement, indicating limited efficacy for this specific melanoma presentation.

Area of Science:

Oncology
Dermatology
Medical Oncology

Background:

Acral lentiginous melanoma is a rare subtype of cutaneous melanoma.
Advanced stages (AJCC Stage IV) present significant treatment challenges.

Purpose of the Study:

To report a case of advanced acral lentiginous melanoma treated with palliative chemotherapy.
To evaluate the treatment response in terms of lymph node metastasis and primary lesion variation.

Main Methods:

A 45-year-old male patient with Stage IV acral lentiginous melanoma of the left sole and lymph node metastasis was treated.
The patient received three cycles of palliative combination chemotherapy.

Main Results:

Chemotherapy led to a decrease in the size of the inguinal lymph node lump.

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The primary melanoma lesion on the sole demonstrated no variation in size or appearance.

Conclusions:

Palliative chemotherapy may offer some benefit in managing metastatic lymph nodes in acral lentiginous melanoma.
The primary tumor on the sole appears refractory to this palliative chemotherapy regimen, suggesting the need for alternative or multimodal treatment strategies.